Commonly cylindical locks are found in a cylinder that can be easily unscrewed by a locksmith to facilitate rekeying. The first main advantage to a cylinder lock, also known as a profile cylinder lock or euro, is that the cylinder can be changed without altering the boltwork hardware. Removing the cylinder typically requires only loosening a set screw, then sliding the cylinder from the boltwork. The second is that it is usually possible to obtain, from various lock manufacturers, cylinders in different formats that can all be used with the same type of key. This allows the user to have keyed-alike, and master-keyed systems that incorporate a wide variety of different types of lock, such as nightlatches, deadbolts and roller door locks.

There are also standardised cross-sectional profiles for lock cylinders that may vary in length - for example to suit different door thicknesses. These profiles include the europrofile (or DIN standard), the British oval profile and the Swiss profile Other varieties